Drugs & Vitamins

Active Ingredients: Tacrolimus
Other Names: Prograf Injection
Product Images & Descriptions:

What is/are Prograf Injection? (Back to top)
TACROLIMUS is used to prevent organ rejection after a transplant. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• diabetes
• heart disease or heart failure
• high blood pressure
• infection
• kidney disease
• an unusual or allergic reaction to tacrolimus, castor oil, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
This does not apply.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• astemizole
• cidofovir
• cisapride
• cyclosporine
• droperidol
• grepafloxacin
• pimozide
• probucol
• ziprasidone

• alcohol and medicines that contain alcohol
• aminoglycosides
• amphotericin B
• antacids
• bromocriptine
• calcium channel blockers like diltiazem, nicardipine, nifedipine, and verapamil
• carbamazepine
• caspofungin
• chloramphenicol
• cimetidine
• cisplatin
• clarithromycin
• danazol
• diuretics
• erythromycin
• ethinyl estradiol
• ganciclovir
• medicines for fungal infections like clotrimazole, fluconazole, itraconazole, ketoconazole, and voriconazole
• metoclopramide
• omeprazole
• phenobarbital
• phenytoin
• protease inhibitors
• rifabutin
• rifampin
• sirolimus
• St. John's wort
• steroid medicines like prednisone or cortisone
• troleandomycin
• vaccines

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• burning or tingling in the hands or feet
• changes in vision
• chest pain
• fever, chills or any other sign of infection
• increased thirst or hunger
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• seizures
• swelling of the feet or legs, unusual or sudden weight gain
• trouble passing urine or change in the amount of urine
• unusual bleeding or bruising
• unusually weak or tired
• yellowing of skin or eyes

• confusion
• constipation
• diarrhea
• difficulty sleeping
• headache
• nausea
• tremors

This list may not describe all possible side effects.

What should I watch for while using this medicine? (Back to top)
Your condition will be monitored carefully while you are receiving this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your blood sugar may increase while you are taking this medicine. Call your doctor or health care professional for advice if you have any of the following symptoms: increased thirst, dry mouth, pass urine frequently, notice a fruity odor on your breath, or feel tired and lose your appetite.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Where should I keep this medicine? (Back to top)
This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:December 13, 2007

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